Do you start the aircraft from a dark&cold state? If so, the problem may be that avionics are not switched on with any of the cockpit switches.

Instead, use a keyboard shortcut for switching on the avionics.


You can see that avionics are on if you tune any ils frequency of the airport you are currently standing on and activate approach mode (flight director must be on) - the dots of the ils markers should turn magenta, which means the ils is received. If avionics are turned off, the dots look like in your screenshot.

Regards,
juergen

Ok, thank you for answer me, the problem was the avionic when started in dark/cold state, so i started with default Cesna aircraft, turn on avionics and reload the 757, now works
Thank you again
Andrea