I usually do a plan for each hop, and save at each airport that I arrive at. then when I restart FSX, all I do is load the saved flight, load the route for the next hop, then check the fuel/pax/cargo for the flight, and off I go.

If I have time to do more than one hop, I pretty nuch do the same thing, and continue on.

Flying from YMML to KLAX, via NFFN and PHNL (or the return flight) is a classic example of my multi hop flights in the 707 Captain.   ;D