I have now been using Windows 10 for awhile.  Using the Captain Sim 777, and flying from KSEA to KSFO, I consistently would get Out of Memory errors with the settings I had previously used with Windows 7 Home Edition.  It appears that the OOM occurs when the VAS (using Process Explorer) gets up to about 3,200,000K.  I have been using 4 monitors - one for the instrument panel and 3 for the forward or spot view.  By only using three monitors, and cutting back on the graphics card settings in fsx I am able to complete this flight without OOM errors.  My Alienware Aurora system has 9 GB of DDR3 RAM,  and I just ordered 24 GB of DDR3 RAM, which hopefully will allow using all four monitors again and higher graphics settings.  I am also using ORBX scenery (PNW, Northern California) for this test flight.

The CS 777 seems to require more VAS than some of the other aircraft, but they also have OOM problems with 4 monitors.  Have not yet tried other CS aircraft, but the 777 flies very well.

Jim Kaye