Maybe you need to try a complete uninstall/reinstall:

If regular reinstall did not fix your problem you can try to clean registry.
Please be careful and do it on your own risk!

How to clean Registry:
1. Uninstall the product
2. Go to Start> Run. Type: regedit, click OK.
3. Find the product entry in HKEY_LOCAL_MACHINE\SOFTWARE\CaptainSim\ (please note, for Windows 64bit versions it is HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\CaptainSim\)
For example: HKEY_LOCAL_MACHINE\SOFTWARE\CaptainSim\C130XPRO
Make sure you are going to delete correct folder!
4. Delete the product entry folder.
5. Restart your computer.
6. Install the product.

If you stil have issues and the above does not help we must admit your system configuration is a rare exception. You can try to install the product on another system or request a refund.

The correct folder to delete in the registry is

HKEY_LOCAL_MACHINE\SOFTWARE\CaptainSim\e732, or

HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\CaptainSim\e732

Then when you need to reactivate it, I recommend you try a Manual Offline Activation.