Search the Support Knowledge Base (I know it's not as easy as it sounds) for a possible solution. Try all that you find.
If  what you find doesn't help, submit a ticket and explain that you have tried the solution that you found, but that they did not work.
If you get an email and your ticket has been cancelled (they provide the KB solution(s) with it).  If you have/do try that/those ones too, and were unsuccessful, submit a new ticket explain they didn't work either.

Mark