I think it would be perfectly safe to re-run the executables...or you could uninstall/reinstall.

I wonder if it could be an FSUIPC version issue?  Grabbing at straws here...maybe check which version of FSUIPC you have installed (I think it's in the 'modules' folder in FSX) and see if it is the most recent one.

FWIW my C-130 is a bit lazy grabbing the localizer...sometimes I have to do the off/on routine with track mode.