Eric,  done....this happened again 2.5 hours into a 3 hour flight.  I simply changed the runway from 35L at KDEN to Rwy 26, selected FUZZZ intersection, tried to close the discontinuity and bam, CTD, game over.

I have had this problem on all flights but one so far, and that one I had the AP not disconnecting problem.

Oh, and changing to FSUIPC 4.3 didn't help me with the AP disconnect problem.  Into KSEA at 200', I disconnected the AP, had no controls and the aircraft landed itself at -600 fpm :o.  I reinstalled FSUIPC 4.3 and was going to try it out again on this flight...but....CTD >:(