I do! Just about gave up on the B757 until I discovered v4.4 which I cleanly installed. I have registered copies of FSUIPC and Wide FS.

Did a test flight today and all I could do was to take off then when I engaged LNAV and VNAV the aircraft turned left and kept turning without any control. VNAV does not follow speed constraints and LNAV don't work.

I forgot to mention that I just reformated my PC which runs on Vista 64 PRO!

On the other hand, I have a friend which has the boxed version and everything works fine with v 4.4! Go FIGURE!  :-/