Hi Sascha,

Did you delete all 757's registry data using regedit.exe before reinstall? If you did, let's try another way.

Try to find CS B-757 default flights. Mine is at LOCAL DISK > PROGRAM FILES (x86) > MICROSOFT GAMES > MICROSOFT FLIGHT SIMULATOR X > CAPTAIN SIM > 757 > FLIGHTS > 757-200 CLEARED FOR TAKEOFF (KSEA).FLT

Double click the file. Windows will ask you to choose a program to open it. Browse up to find MSFS > OK

Create a new flight from KSEA to another airport and follow all steps as you usually do, entering all data at FMC.

Don't forget to check if Flight Director F/D is ON.

Tell us if the problem persists.

Good luck,

Pinatubo.