Well, this is not a support thing like the Autopilot one, and while I have gone through that thread to only find user errors that are not the ones I do (Did them when I started on the 747)

The reason I am posting is that it is starting to get on my nerves and I am unsure if I can blame the aircraft or my lack of knowledge at the moment.
In short, anything here that is different from a general setup on the another company contra CaptainSim?